BODIO Ewen See the English profil sheet English (EN)

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  • BODIO Ewen
  • Statut : Professeur(e)
  • Équipe : OCS
  • Fonction : Chercheurs et enseignants chercheurs
  • Seconde équipe : Search support
  • Fonction au sein de la deuxième équipe : Personnel technique et informatique
  • Tags : Chimie Bio(in)organique, Chimie de Coordination, Imagerie Moléculaire, Chimie de Synthèse
  • Adresse :

    ICMUB Institut de Chimie Moléculaire de l'Université de Bourgogne
    Bât. MIRANDE - Bureau B220
    9 Avenue Alain Savary
    21000 Dijon – France

  • Tél : (+33) 380 396 076
  • ewen.bodio@u-bourgogne.fr

Since 2024  Deputy Director of ICMUB
(Institut de Chimie Moléculaire de l’Université de Bourgogne UMR CNRS 6302)

Since 2019  Full Professor ICMUB (1st class since 2023)
P.I. of metal-based theranostics and azaMDIPY axes and co-P.I. of aza-BODIPYs axis
Main project: Design of theranostics, bimodal probes, near-infrared optical probes for applications in in vitro and in vivo medicine.
Main fields of expertise: organic chemistry, coordination chemistry, bioinorganic, medical imaging (optical, PET, SPECT), catalysis  

2010-2019  Assistant Professor ICMUB
Group P.I.: Prof. Pierre Le Gendre
Organic and organometallic synthesis applied to medical imaging, therapy, and catalysis

2009-2010  Postdoctoral position (ERC grant) School of Chemistry, Trinity College 
University of Dublin, Ireland
Supervisor: Prof. Stephen Connon
Organocatalysis, amines kinectic resolution, and design of artificial enzyme

2006-2009  PhD (CNRS grant) CEISAM Lab
(Chimie Et Interdisciplinéarité: Synthèse, Analyse, Modélisation), UMR CNRS 6230 of Université de Nantes, France
Supervisor: Prof. David Deniaud – Co-supervisor: Dr Karine Julienne
Synthesis of « N2S2 » / « N4 » chelating agents for nuclear medicine applications

2005-2006  Master in Biomolecular Engineering - Montpellier (UMII), France

2003-2006  « Ingénieur en Chimie » - ENSIACET, Toulouse, France
Specialization in advanced organic chemistry at ENSCM, Montpellier, France

 

Main projects as Principal Investigator (or co-P.I.)

- Lipid derivatives against obesity 2023 (financement EktaH® ≈ 190 k€)
- ICE CasYNIR-II 2023 (BFC regional contract for start-up creation – 50 k€)
- FluoNIR-II 2022 (maturation contract for start-up creation – 260 k€)
- ANR PRC 2021 “MAP” (Metal azaDIPY probe – 520 k€)
- ANER 2020 “AZTHEC” (Metal-based aza-BODIPY – 129 k€)
- ANR JCJC 2016 “SPID” (Smart Probe for Imaging metal-based Drugs – 230 k€)
- PARI II – 3-p2 (metal-based theranostics – 75 k€)
- BQR PRESS (biosourced theranostics – 15 k€)
- projet INFIniTI – CNRS SIIM (theoretical study of smart probes – 3 k€)
- 3 JCE/ICE PhD program (young researcher-entrepreneur – 3x 99 k€)
- PARI p5 subproject of 3MIM program (Trackable metal-based therapeutics – 180 k€)
- “bioinorganic and medicinal chemistry” theme of the ICMUB - “Health axis” of OCS Team

+ Several other projects as WP leader or participant

 

Publications
H index = 24 (google scholar)
Type of publications published
Articles 51 (31)*
Reviews and book chapters 7 (5)*
Intellectual property 4 (2)*
Proceedings 5
Total 67 (38)*
* as corresponding author

Last Publications 

A-51

Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates

Chazeau E., Fabre C., Privat M., Godard A., Racoeur C., Bodio E., Busser B., Wegner K. D., Sancey L.*, Paul C.*, Goze C.*

J. Med. Chem., 2024, ASAP

https://doi.org/10.1021/acs.jmedchem.3c02139
A-50

Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models

Privat M., Massot A., Hermetet F., Al Sabea H., Racoeur C., Mabrouk N., Cordonnier M., Moreau M., Collin B., Bettaieb A., Denat F., Bodio E.*, Bellaye P.-S., Goze C.*, Paul, C.*

J. Med. Chem., 2024, 67(3), 2188-2201.

https://doi.org/10.1021/acs.jmedchem.3c02120
A-49

Al(III) and Ga(III) Bisphenolate Azadipyrromethene-Based "N2O2" Complexes as Efficient NIR-Fluorophores

Godard, A., Galan, L. A., Rouillon, J., Al Shehimy, S., Tajani, W., Cave, C., Malacea-Kabbara, R., Rousselin, Y., Le Gendre, P., Fihey, A., Bendellaa, M., Busser, B., Sancey, L., Le Guennic, B., Bucher, C., Maury, O., Goze, C., Bodio, E.*

Inorg. Chem., 2023, 62 (13), 5067-5080.

https://doi.org/10.1021/acs.inorgchem.2c03918

Couverture
A-48

NIR-II Aza-BODIPY Dyes Bioconjugated to Monoclonal Antibody Trastuzumab for Selective Imaging of HER2-Positive Ovarian Cancer

Godard, A., Kalot, G., Privat, M., Bendellaa, M., Busser, B., Wegner, K. D., Denat, F., Le Guével, X., Coll, J.-L., Paul, C.,* Bodio, E., Goze,* C., Sancey, L.*

J. Med. Chem. 2023, 66 (7), 5185–5195.

https://doi.org/10.1021/acs.jmedchem.3c00100.
A-47

Bis(Salicylamidine) Ligands (FAlen): A Variant of Salen with “à La Carte” Denticity

Vaillant-Coindard, V., Chotard, F., Théron, B., Balan, C., Bayardon, J., Malacea-Kabbara, R.,* Bodio, E., Rousselin, Y., Fleurat-Lessard, P., Le Gendre, P.*

Inorg. Chem. 2023, 62 (19), 7342–7352.

https://doi.org/10.1021/acs.inorgchem.3c00493.
A-46

First Comparison Study of the In Vitro and In Vivo Properties of a Randomly and Site-Specifically Conjugated SPECT/NIRF Monomolecular Multimodal Imaging Probe (MOMIP) Based on an Aza-BODIPY Fluorophore

Privat, M., Bellaye, P.-S., Chazeau, E., Racoeur, C., Adumeau, P., Vivier, D., Bernhard, C., Moreau, M., Collin, B., Bettaieb, A., Denat, F., Bodio, E., Paul, C.,* Goze, C.*

Bioconjug. Chem. 2023, 34(4), 621-628.

https://doi.org/10.1021/acs.bioconjchem.3c00080.

Recent patents

Sancey, L., Goze, C., Bodio, E., Busser, B., Pliquett, J., Godard, A., Kalot, G., Josserand, V., Le Guével, X., Coll, J.L., Denat, F.
Université Grenoble Alpes, CNRS, INSERM, Univ. de Bourgogne
Eur. Pat. Appl. (2021), EP 3772528 A1 20210210
PCT Int. Appl. (2021), WO 2021023731 A1 20210211
US Patent App. (2022), 17/633,610, 2022

 

Communications**
Types Total International
Invited lecture 1 1
Oral com’ 27 6
Seminars 8 1
Posters 16 8
Total 47 15
**Communications as presenter

 

Teaching
2010 - ... > 230 h/year (CM/TD/TP – L3/M1/M2) / 2022-2023 (≈ 260 h)
- organic chemistry (retrosynthesis, total synthesis...) [bachelor/Master]
- Spectroscopic methods [Bachelor/Master]
- Molecular imaging [Master]
- Theranostics [Master]
- Environnemental analyses [Master]
- Project management [Master]

Teaching Responsabilities
2019 - ... Head of international Molecular Chemistry Master
2019 - ... M1 Innovative Drugs pedagogical advisor (molecular chemistry)
2017 - ... Co-leader of double degree with UCT Prague
2016 - ... Head of T2MC Master Specialty (Transition Metal in Molecular Chemistry)
2013 - ... Creation of an international master in imaging (Master LipTherapy)

Project management
P.I. of the I-site Master international Molecular Chemistry project
P.I. of PIA 3 - RITM-BFC project on pedagogical innovation
Co-leader of the project I-SITE “strengthened bachelor”
WP leader of the Graduate school UBFC Integrate
WP leader of the I-site Master international Innovative Drugs project

 

Administratives Responsabilities

2022 - ...   Member of “bureau de la commission de proposition section 31-32-33 de l’uB”
2020 - 21  Member of CNRS National committee « chemistry for life sciences » - section 16
2017 - ...   Communication manager of ICMUB
2014 - ...   IT advisor of the ICMUB
2012 - 19  Committee Member of Scientific council of ICMUB