2D/3D Covalent Organic Frameworks based on cobalt corroles for CO binding (Materialstoday Chemistry - 2023)
Interrogating G-quadruplex (G4) biology at its deepest roots in human cells relies on the design, synthesis, and use of ever smarter molecular tools.
In this article, we designed a biomimetic G4 ligand referred to as BioTriazoTASQ in which a biotin handle was incorporated. BioTriazoTASQ was used as a molecular bait for fishing G4s by affinity purification protocols. Its versatility was then further demonstrated by optical imaging that provided unique mechanistic insights into the actual strategic relevance of G4-targetting strategies, showing that ligand-stabilized G4 sites colocalize with and, thus, are responsible for DNA damage foci in human cells.
Now published in JACS Au: Click chemistry-based biomimetic ligands efficiently capture G-quadruplexes in vitro and help localize them at DNA damage sites in human cells. Francesco Rota Sperti, Baptiste Dupouy, Jérémie Mitteaux, Angélique Pipier, Marc Pirrotta, Nicolas Chéron, Ibai E. Valverde and David Monchaud, JACS Au, 2, 1588, https://doi.org/10.1021/jacsau.2c00082.
A new publication in Nucleic Acids Research
Genome-wide studies of DNA G- and C-quadruplexes (G4s and i-motifs, respectively) can boost the pace of progress towards a comprehensive understanding of their biological implications and practical applications in plants. In this review, we summarize the current state of knowledge about omics studies in order to highlight the current challenges and propose future directions to take studies of plant quadruplexes to the next step.
Omics studies of G-/C-quadruplexes in plants
Mengqi Li, Ruiping Tian, David Monchaud and Wenli Zhang
Trends in Genetics, https://doi.org/10.1016/j.tig.2022.06.005
Global mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq
Covalent grafting of aryls to modulate the electrical properties of phthalocyanine-based heterostructures: Application to ammonia sensing
Between digold and nanoparticles : the selectivity of tetragold cationic catalyst
The genuine transmission pathways of indirect nuclear spin-spin couplings in high resolution nuclear magnetic resonance is notably conceptually poorly understood in complex expertimental situations in which both nonbonded ["through-space" (TS)] and "classical" bonding ("through-bond") spin-spin coupling pathways are potentially involved.
We presented theoretical approaches for analyzing the transmission pathways of indirect neclear spin-spin couplings in high-resolution nuclear magnetic resonance. The computational approaches we proposed allow the visualization and discussion of individual transmission pathways to give for the first time an estimation of their relative weight from numerical contributions to the spin-spin coupling constant J-value.
It evidenced and modeled for the first time the existence of spin-spin transmission pathways mixing classical covalent bonding parts with a lone pair overlap of proximate heteroatoms (P and Se).
The genuine transmission pathways of indirect nuclear spin-spin couplings in high resolution nuclear magnetic resonance is notably conceptually poorly understood in complex expertimental situations in which both nonbonded ["through-space" (TS)] and "classical" bonding ("through-bond") spin-spin coupling pathways are potentially involved.
We presented theoretical approaches for analyzing the transmission pathways of indirect neclear spin-spin couplings in high-resolution nuclear magnetic resonance. The computational approaches we proposed allow the visualization and discussion of individual transmission pathways to give for the first time an estimation of their relative weight from numerical contributions to the spin-spin coupling constant J-value.
It evidenced and modeled for the first time the existence of spin-spin transmission pathways mixing classical covalent bonding parts with a lone pair overlap of proximate heteroatoms (P and Se).
