Two new articles in Nucleic Acids Research

Two articles by Monchaud et al. have been accepted for publication in Nucleic Acids Res., one of the leading journals in genetics (IF = 19.2). In the first one (NAR-1 2022), we explored the roles that G-quadruplexes (G4s) play in stress granules (SG) formation and dynamics. This study is two-fold, combining an experimental approach aimed at discovering by which cellular processes G4s act on SG formation, and a computational approach in which a machine learning tool (rG4detector) was developed to predict G4 formation. This work was done in collaboration with Eran Hornstein's lab, at the Weizmann Institute of Science, Rehovot (Israel). The second one (NAR-2 2022) is a review that summarizes the current state of knowledge about DNA junctions (three- and four-way DNA junctions), encompassing their structures and biological relevance along with a description of the cellular consequences of their stabilization by ad hoc ligands for therapeutic purposes. This review was written in collaboration with Christine Cardin at Reading, UK.